Miyakawa T, Katsuragi S, Araki K, Hashimura T, Kimura T, Kuramoto R
Department of Neuropsychiatry, Kumamoto University Medical School, Japan.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;57(4):267-73. doi: 10.1007/BF02899091.
The ultrastructure of neurofibrillary tangles (NFT) was examined by electron microscopy. The fibrils of NFT seemed to consists of about eight protofilaments consisting of globular subunits; these protofilaments were helically wound in a longitudinal direction. The fibrils of NFT had hollow structures at their centers surrounded by the eight globular subunits. The subunits were tightly connected in the narrow parts of the fibril, but more loosely connected in the wider parts. From these findings, it seemed that the fibrils of NFT consist of a twisted tubule having periodical constrictions and is made up of eight helically wound protofilaments, forming globular subunits.
通过电子显微镜检查神经原纤维缠结（NFT）的超微结构。NFT的纤维似乎由大约八条由球状亚基组成的原纤维构成；这些原纤维在纵向上呈螺旋状缠绕。NFT的纤维在其中心具有中空结构，周围环绕着八个球状亚基。亚基在纤维的狭窄部分紧密相连，但在较宽部分连接较松散。从这些发现来看，NFT的纤维似乎由具有周期性收缩的扭曲小管组成，并且由八条螺旋状缠绕的原纤维构成，形成球状亚基。
