Rossi Davide, De Paoli Lorenzo, Franceschetti Silvia, Capello Daniela, Vendramin Chiara, Lunghi Monia, Conconi Annarita, Magnani Corrado, Gaidano Gianluca
Division of Haematology, Department of Clinical and Experimental Medicine and IRCAD, Amedeo Avogadro University of Eastern Piedmont and Ospedale Maggiore della Carità, Novara, Italy.
Br J Haematol. 2007 Jul;138(2):249-52. doi: 10.1111/j.1365-2141.2007.06633.x. Epub 2007 May 29.
Monoclonal gammopathy of uncertain significance (MGUS) may become symptomatic for autoimmune manifestations. We report on the prevalence and clinical course of immune thrombocytopenic purpura (ITP) observed in a consecutive series of 228 MGUS patients. At MGUS diagnosis, ITP was determined in 6/228 cases, accounting for a prevalence of 2630/100 000 [95% confidence interval (CI): 1210-5620]. One incidental ITP case occurred after 21 months of follow-up. After a follow-up of 681.3 patient-years, the crude incidence of ITP in MGUS was 146.8 per 100 000 patient-year (95% CI: 3.7-817.8). Overall, these observations point to an association between MGUS and ITP.
意义未明的单克隆丙种球蛋白病（MGUS）可能因自身免疫表现而出现症状。我们报告了在连续的228例MGUS患者系列中观察到的免疫性血小板减少性紫癜（ITP）的患病率和临床病程。在MGUS诊断时，228例中有6例被确定为ITP，患病率为2630/100000[95%置信区间（CI）：1210 - 5620]。1例偶然的ITP病例在随访21个月后出现。经过681.3患者年的随访，MGUS中ITP的粗发病率为每100000患者年146.8（95%CI：3.7 - 817.8）。总体而言，这些观察结果表明MGUS与ITP之间存在关联。
