新诊断的冒烟型骨髓瘤和结直肠癌患者免疫性血小板减少症的管理
Management of immune thrombocytopoenia in a patient with newly-diagnosed smouldering myeloma and colorectal cancer.
作者信息
Siniscalchi Agostina, Stasi Roberto, Fratoni Stefano, de Fabritiis Paolo, Caravita Tommaso
机构信息
S Eugenio Hospital, Department of Hematology, Piazzale le dell'Umanesimo, 10, Rome, 00144, Italy.
出版信息
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.03.2009.1715. Epub 2009 Jun 11.
Abstract
Immune thrombocytopoenia (ITP) is one of the most common autoimmune manifestations of B cell lymphoproliferative diseases. The association with multiple myeloma (MM) and solid tumours is rare. Here, a case of ITP associated with asymptomatic multiple myeloma and colon carcinoma, refractory to standard therapy and responsive to rituximab, is described. ITP should be considered in the differential diagnosis of thrombocytopoenia in MM and colon cancer. Understanding of the potential risk and reversibility of ITP should aid in the management of these patients.
摘要
免疫性血小板减少症（ITP）是B细胞淋巴增殖性疾病最常见的自身免疫表现之一。与多发性骨髓瘤（MM）和实体瘤相关的情况较为罕见。在此，描述了1例与无症状性多发性骨髓瘤和结肠癌相关的ITP病例，该病例对标准治疗无效，但对利妥昔单抗有反应。在MM和结肠癌患者血小板减少症的鉴别诊断中应考虑ITP。了解ITP的潜在风险和可逆性应有助于这些患者的管理。
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