Rathe F, Auschill T M, Sculean A, Gaudszuhn Ch, Arweiler N B
Department of Operative Dentistry & Periodontology, Dental School and Hospital Freiburg, Albert-Ludwigs-University, Freiburg, Germany.
J Clin Periodontol. 2007 Aug;34(8):646-51. doi: 10.1111/j.1600-051X.2007.01099.x. Epub 2007 May 29.
The aim of the study was to determine the plaque and gingivitis reducing effect of a dentifrice containing chlorhexidine and aluminium lactate compared with a control toothpaste during the course of 6 months.
This randomized, double-blind study looked prospectively at participants over a 6-month period. Plaque, gingivitis, calculus formation and tooth staining were assessed in 59 participants, who were divided into parallel groups. The participants used either a chlorhexidine and aluminium lactate-containing toothpaste (test group) or a minus active control toothpaste (control group). Parameters were assessed at baseline and again after 1, 3 and 6 months.
After 6 months of product use, both groups had less gingivitis compared with the baseline evaluation (p<0.001). At this time point, the test group showed a statistically significant lower gingival index values compared with the control group (p=0.001). No statistically significant differences between either the groups or time points were detected with regard to plaque index and the development of calculus and staining.
Although there was a statistically significant difference at 6 months between test and control groups, this difference was too small to be considered clinically meaningful.
本研究旨在确定含氯己定和乳酸铝的牙膏与对照牙膏相比,在6个月期间减少牙菌斑和牙龈炎的效果。
这项随机双盲研究前瞻性地观察了参与者6个月。对59名参与者进行了牙菌斑、牙龈炎、牙结石形成和牙齿染色的评估,这些参与者被分为平行组。参与者使用含氯己定和乳酸铝的牙膏(试验组)或不含活性成分的对照牙膏(对照组)。在基线时以及1、3和6个月后再次评估各项参数。
使用产品6个月后,与基线评估相比,两组的牙龈炎均有所减轻(p<0.001)。在这个时间点,试验组的牙龈指数值与对照组相比有统计学意义的显著降低(p=0.001)。在牙菌斑指数、牙结石形成和染色方面,两组之间或各时间点之间均未检测到统计学上的显著差异。
虽然试验组和对照组在6个月时存在统计学上的显著差异,但这种差异太小,不具有临床意义。