Olympio K P K, Bardal P A P, de M Bastos J R, Buzalaf M A R
Department of Pedodontics, Orthodontics and Collective Health, Bauru Dental School, University of São Paulo, São Paulo, Brazil.
J Clin Periodontol. 2006 Jun;33(6):421-6. doi: 10.1111/j.1600-051X.2006.00927.x.
This blind and randomized-controlled trial analysed chlorhexidine dentifrices in relation to dental plaque, gingivitis, bleeding, calculus and enamel extrinsic staining development. Volunteers in fixed orthodontic therapy used the following dentifrices: 1100 ppmF, NaF (group A, n=27); experimental, 1100 ppmF, NaF and chlorhexidine 0.95% (group B, n=28); and experimental, chlorhexidine 0.95% (group C, n=28). At baseline, after 6, 12 and 24 weeks, clinical examinations were carried out. The gingivitis, bleeding and plaque data were tested by anova and Tukey's post hoc tests. Stain and calculus data were analysed by Kruskal-Wallis and Dunn's post hoc tests (p<0.05). Plaque, gingivitis and bleeding scores improved in all three groups, but up to the 6 and 12 weeks examination the products containing chlorhexidine were statistically better. The chlorhexidine dentifrices significantly increased the mean of the stain index, although most of the patients did not notice the stains. The calculus index was not significantly modified. In summary, this study suggests that the use of dentifrices containing chlorhexidine seems to be effective for the treatment of gingivitis in orthodontic patients, although the intense motivating contact that the volunteers had with the researchers may have also played a role.
这项双盲随机对照试验分析了洗必泰牙膏与牙菌斑、牙龈炎、出血、牙石及牙釉质外源性染色形成之间的关系。接受固定正畸治疗的志愿者使用了以下几种牙膏：含1100 ppm氟的氟化钠牙膏（A组，n = 27）；试验性牙膏，含1100 ppm氟的氟化钠和0.95%洗必泰（B组，n = 28）；以及试验性牙膏，0.95%洗必泰（C组，n = 28）。在基线期、6周、12周和24周后进行了临床检查。牙龈炎、出血和牙菌斑数据采用方差分析和Tukey事后检验。染色和牙石数据采用Kruskal-Wallis检验和Dunn事后检验（p<0.05）。三组的牙菌斑、牙龈炎和出血评分均有所改善，但在6周和12周检查时，含洗必泰的产品在统计学上表现更好。洗必泰牙膏显著增加了染色指数的平均值，尽管大多数患者并未注意到染色情况。牙石指数没有显著变化。总之，本研究表明，使用含洗必泰的牙膏似乎对正畸患者的牙龈炎治疗有效，尽管志愿者与研究人员密切频繁的接触可能也起到了一定作用。
