Locatelli M, Buzzetti R, Galgani A, Montemari A L, Khazrai M, Petrone A, Visalli N, Meschi F, Minicucci L, Lorini R, Cristaldi A, Valorani M G, Bottazzo G F, Pozzilli P
Scientific Directorate, Bambino Gesù Pediatric Hospital, Rome, Italy.
Diabet Med. 2007 Aug;24(8):916-9. doi: 10.1111/j.1464-5491.2007.02192.x. Epub 2007 May 29.
The aim of this study, which is part of the ongoing DIABFIN project, was to correlate HLA class II genotypes, classified for their effect on susceptibility to Type 1 diabetes (T1D), with various risk factors during pregnancy and the neonatal period.
Cord blood was collected from 4349 neonates; 1.0% were at high HLA risk (HR), 9.0% at moderate HLA risk (MR), and 90.0% at low HLA risk (LR) for T1D. Information about the mother's pregnancy, type of delivery, the neonates' clinical features at birth, and family history for autoimmune diseases were collected.
Significant correlations were found between the different HLA risk categories and length of gestation, even when adjusted for sex, weight and length at birth of the neonate, birth order and mother's age (adjusted P = 0.007). The male : female ratio tended to increase from the LR to the HR category, from 1.00 and 1.21, respectively, in the LR and MR groups, to 1.62 in the HR group (P = 0.05).
Length of gestation is inversely correlated with HLA risk categories for T1D. The higher the HLA risk for T1D, the shorter the gestational age, especially in male neonates.
本研究是正在进行的DIABFIN项目的一部分，旨在将根据对1型糖尿病（T1D）易感性的影响分类的HLA II类基因型与孕期和新生儿期的各种风险因素相关联。
收集了4349例新生儿的脐带血；其中1.0%为T1D的高HLA风险（HR），9.0%为中度HLA风险（MR），90.0%为低HLA风险（LR）。收集了母亲孕期、分娩方式、新生儿出生时的临床特征以及自身免疫性疾病家族史等信息。
即使在对新生儿的性别、出生体重和身长、出生顺序及母亲年龄进行校正后，不同HLA风险类别与妊娠时长之间仍存在显著相关性（校正P = 0.007）。男女比例从LR组到HR组呈上升趋势，LR组和MR组分别为1.00和1.21，HR组为1.62（P = 0.05）。
妊娠时长与T1D的HLA风险类别呈负相关。T1D的HLA风险越高，胎龄越短，尤其是男性新生儿。
