Sehgal Virendra N
Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, Panchwati, Azadpur, Delhi, India.
J Dermatol. 2007 Jun;34(6):361-6. doi: 10.1111/j.1346-8138.2007.00289.x.
Twenty nail dystrophy (TND) trachyonychia, a fascinating clinical condition, was brought to focus 25 years ago. Ever since, it has been sparingly reported. Nonetheless, the condition is well-recognized and its diagnosis is made on the basis of clinical features characterized by onset in infancy/childhood, and occasionally in adults. The lesions are fairly representative, and are characterized by the alternating elevation and depression (ridging) and/or pitting, lack of luster, roughening likened to sandpaper, splitting, and change to a muddy grayish-white color. Dystrophy is prominent. Several modes of occurrence have been described including an hereditary component. The confirmation of diagnosis is through microscopic pathology corresponding either to endogenous eczema/dermatitis, lichen-planus like or psoriasic-form. It is a self-limiting condition and may occasionally require intervention.
二十甲营养不良（TND）糙甲症，一种引人关注的临床病症，于25年前开始受到关注。自那时起，相关报道较少。尽管如此，该病症已得到充分认识，其诊断基于临床特征，这些特征表现为发病于婴儿期/儿童期，偶尔也见于成人。病变具有相当的代表性，其特征为高低不平（嵴状）和/或凹坑交替出现、缺乏光泽、粗糙如砂纸、指甲裂开以及变为浑浊的灰白色。营养不良较为显著。已描述了多种发病方式，包括遗传因素。诊断的确立需通过与内源性湿疹/皮炎、扁平苔藓样或银屑病样相对应的微观病理学检查。这是一种自限性病症，偶尔可能需要干预。
