Kozlovskiĭ V I
Kardiologiia. 1991 Oct;31(10):17-9.
A total of 56 patients with Functional Class II angina pectoris and 25 healthy subjects were examined. Long-acting nitrates were ascertained to result in profound venular dilatation, slight arteriolar dilatation, moderately decreased erythrocyte aggregation and improvement of tissue oxygen supply. The most marked increase in exercise tolerance and reduction in the frequency of anginal attacks were noted in patients with normal and narrowed venules. There were no significant changes in microcirculation and exercise tolerance in patients with baseline dilated venules. It is concluded that the microvasculature may be one of the criteria for applying long-acting nitrates in patients with coronary heart disease on an individual basis.
共检查了56例II级功能性心绞痛患者和25名健康受试者。确定长效硝酸盐可导致显著的小静脉扩张、轻微的小动脉扩张、红细胞聚集适度减少以及组织氧供应改善。在小静脉正常和狭窄的患者中，观察到运动耐量最显著增加，心绞痛发作频率降低。基线小静脉扩张的患者微循环和运动耐量无显著变化。结论是，微血管系统可能是冠心病患者个体化应用长效硝酸盐的标准之一。
