Kirichenko L L, Masenko V P, Evdokimova A G, Iunusov M A
Kardiologiia. 1992 Apr;32(4):8-10.
Platelet aggregation and prostaglandin levels were examined in 50 patients with coronary heart disease concurrent with Functional Classes II-III angina who received nitroglycerin-retard (n = 20; Group 1), corovas (n = 20; Group 2), and placebo (n = 10; Group 3). Long-acting nitrates were found to exert a positive action on thrombocytic hemostasis as decreased platelet aggregation and reverse aggregation in 25% of the corovas-treated patients. Placebo failed to have the same action. Nitroglycerin-retard caused an increase in prostacyclin concentrations. Nitroglycerin-retard and corovas produced a clear-cut antianginal effect. They promoted the reduction in the number of anginal episodes and of nitroglycerin tablets used. No antianginal effect was absent when placebo was used.
对50例患有冠心病并发II - III级心绞痛的患者进行了血小板聚集和前列腺素水平检测，这些患者分别接受了缓释硝酸甘油（n = 20；第1组）、可洛伐斯（n = 20；第2组）和安慰剂（n = 10；第3组）治疗。发现长效硝酸盐对血小板止血有积极作用，在25%接受可洛伐斯治疗的患者中血小板聚集减少且出现反向聚集。安慰剂没有相同作用。缓释硝酸甘油使前列环素浓度升高。缓释硝酸甘油和可洛伐斯产生了明显的抗心绞痛作用。它们促使心绞痛发作次数和所用硝酸甘油片数量减少。使用安慰剂时未出现抗心绞痛作用。
