降钙素/降钙素受体调节破骨细胞细胞骨架组织和骨吸收活性的信号转导途径。
Signal transduction pathways of calcitonin/calcitonin receptor regulating cytoskeletal organization and bone-resorbing activity of osteoclasts.
作者信息
Tanaka S, Suzuki H, Yamauchi H, Nakamura I, Nakamura K
机构信息
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
出版信息
Cell Mol Biol (Noisy-le-grand). 2006 May 30;52(3):19-23.
PMID:17535750
Abstract
Calcitonin is a calcium-regulating peptide hormone that acts directly on osteoclasts and suppresses their function. In this review we will focus on the downstream signaling pathways of calcitonin receptor regulating cytoskeletal organization of osteoclasts. We will also introduce the clinical application of the hormone for metabolic bone diseases.
摘要
降钙素是一种调节钙的肽类激素，它直接作用于破骨细胞并抑制其功能。在本综述中，我们将聚焦于降钙素受体的下游信号通路，该通路调节破骨细胞的细胞骨架组织。我们还将介绍该激素在代谢性骨病中的临床应用。
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