Valdés Sergio, Botas Patricia, Delgado Elias, Alvarez Francisco, Cadórniga Francisco Diaz
Endocrinology and Nutrition, Hospital Central de Asturias, Oviedo, Spain.
Diabetes Care. 2007 Sep;30(9):2258-63. doi: 10.2337/dc06-2461. Epub 2007 May 29.
The aim of this study was to define the incidence of type 2 diabetes in a low-risk Caucasian population in northern Spain and its association with various risk factors.
The Asturias Study is a prospective, population-based survey of diabetes and cardiovascular risk factors. The baseline examination was carried out during 1998-1999 when 1,034 individuals, aged 30-75 years, were randomly selected to determine the prevalence of type 2 diabetes and pre-diabetes in the Principality of Asturias (northern Spain). In 2004-2005, these same subjects were invited for a follow-up examination; 700 participated. This study includes only those individuals who did not have diabetes at baseline. We used the World Health Organization 1999 criteria to classify glucose metabolism at both baseline and follow-up.
The incidence of diabetes adjusted for the age and sex structure of Asturias was 10.8 cases/1,000 person-years (95% CI 8.1-14.8). The incidence rates were 5 cases/1,000 person-years in individuals with normoglycemia, 21 cases/1,000 person-years in individuals with isolated impaired glucose tolerance (IGT), 34.7 cases/1,000 person-years in individuals with isolated impaired fasting glucose (IFG), and 95.2 cases/1,000 person-years in individuals with combined IFG-IGT. Stepwise multiple logistic regression analysis showed that, together with fasting plasma glucose (FPG) and 2-h plasma glucose, which were the strongest predictors of diabetes, triglycerides and BMI were also independently associated with progression to diabetes.
In this 6-year prospective population-based study, we found an incidence of type 2 diabetes of 10.8 cases/1,000 person-years. Both FPG and 2-h plasma glucose were strongly predictive of diabetes, and their effect was additive.
本研究旨在确定西班牙北部低风险白种人群中2型糖尿病的发病率及其与各种风险因素的关联。
阿斯图里亚斯研究是一项基于人群的糖尿病和心血管风险因素前瞻性调查。1998年至1999年进行了基线检查，随机选取了1034名年龄在30至75岁之间的个体，以确定阿斯图里亚斯公国（西班牙北部）2型糖尿病和糖尿病前期的患病率。2004年至2005年，邀请这些受试者进行随访检查；700人参与。本研究仅包括那些在基线时没有糖尿病的个体。我们使用世界卫生组织1999年标准对基线和随访时的糖代谢进行分类。
根据阿斯图里亚斯的年龄和性别结构调整后的糖尿病发病率为10.8例/1000人年（95%可信区间8.1 - 14.8）。血糖正常个体的发病率为5例/1000人年，单纯糖耐量受损（IGT）个体为21例/1000人年，单纯空腹血糖受损（IFG）个体为34.7例/1000人年，IFG-IGT合并个体为95.2例/1000人年。逐步多元逻辑回归分析表明，除了空腹血糖（FPG）和2小时血糖是糖尿病最强的预测因素外，甘油三酯和BMI也与糖尿病进展独立相关。
在这项为期6年的基于人群的前瞻性研究中，我们发现2型糖尿病的发病率为10.8例/1000人年。FPG和2小时血糖均强烈预测糖尿病，且其作用是相加的。
