Söti C, Csermely Péter
Department of Medical Chemistry, Semmelweis University PO Box 260, H-1444, Budapest 8, Hungary.
J Biosci. 2007 Apr;32(3):511-5. doi: 10.1007/s12038-007-0050-z.
Environmental stress induces damage that activates an adaptive response in any organism. The cellular stress response is based on the induction of cytoprotective proteins,the so called stress or heat shock proteins. The stress response as well as stress proteins are ubiquitous,highly conserved mechanism, and genes, respectively, already present in prokaryotes. Chaperones protect the proteome against conformational damage, promoting the function of protein networks. Protein damage takes place during aging and in several degenerative diseases, and presents a threat to overload the cellular defense mechanisms. The preservation of a robust stress response and protein disposal is indispensable for health and longevity. This review summarizes the present knowledge of protein damage, turnover, and the stress response in aging and degenerative diseases.
环境应激会诱导损伤，从而激活任何生物体中的适应性反应。细胞应激反应基于细胞保护蛋白的诱导，即所谓的应激蛋白或热休克蛋白。应激反应以及应激蛋白分别是原核生物中已存在的普遍且高度保守的机制和基因。伴侣蛋白保护蛋白质组免受构象损伤，促进蛋白质网络的功能。蛋白质损伤在衰老过程和几种退行性疾病中发生，并对细胞防御机制的超负荷构成威胁。维持强大的应激反应和蛋白质处理能力对于健康和长寿不可或缺。本综述总结了目前关于衰老和退行性疾病中蛋白质损伤、周转及应激反应的知识。
