The nonlinear material properties of liver tissue determined from no-slip uniaxial compression experiments.

The mechanical response of soft tissue is commonly characterized from unconfined uniaxial compression experiments on cylindrical samples. However, friction between the sample and the compression platens is inevitable and hard to quantify. One alternative is to adhere the sample to the platens, which leads to a known no-slip boundary condition, but the resulting nonuniform state of stress in the sample makes it difficult to determine its material parameters. This paper presents an approach to extract the nonlinear material properties of soft tissue (such as liver) directly from no-slip experiments using a set of computationally determined correction factors. We assume that liver tissue is an isotropic, incompressible hyperelastic material characterized by the exponential form of strain energy function. The proposed approach is applied to data from experiments on bovine liver tissue. Results show that the apparent material properties, i.e., those determined from no-slip experiments ignoring the no-slip conditions, can differ from the true material properties by as much as 50% for the exponential material model. The proposed correction approach allows one to determine the true material parameters directly from no-slip experiments and can be easily extended to other forms of hyperelastic material models.