Lopez D M, Ortiz-Muniz G, Sigel M M
Proc Soc Exp Biol Med. 1976 Jan;151(1):225-30. doi: 10.3181/00379727-151-39179.
Lymphocytes of MTV-negative Balb/c mice are sensitive to one or more antigens of MTV as determined by blastogenic transformation and migration inhibition assays. The lymphocytes from MTV-positive Balb/cfC3H mice are nonresponsive in these assays but become responsive after the mice have been implanted with MTV-positive tumors. The latter findings imply that there may be either a state of tolerance to MTV antigens which is broken by the tumor transplant or that the responses are directed towards antigens to which the host is not tolerant. The cause of the sensitivity of lymphocytes from MTV-negative Balb/c mice to MTV antigens has not been determined but two possible explanations are discussed: horizontal transmission and derepression of genetic information for viral antigen.
通过胚细胞转化和迁移抑制试验确定，MTV阴性的Balb/c小鼠的淋巴细胞对MTV的一种或多种抗原敏感。来自MTV阳性的Balb/cfC3H小鼠的淋巴细胞在这些试验中无反应，但在小鼠植入MTV阳性肿瘤后会变得有反应。后一发现意味着可能存在对MTV抗原的耐受状态，这种状态被肿瘤移植打破，或者反应是针对宿主不耐受的抗原。MTV阴性的Balb/c小鼠的淋巴细胞对MTV抗原敏感的原因尚未确定，但讨论了两种可能的解释：水平传播和病毒抗原遗传信息的去抑制。
