Gude Anne-Bolette Jill, Hoegberg Lotte C G, Pedersen Michael, Nielsen Jonas, Angelo Helle R, Christensen Hanne Rolighed
Bispebjerg Hospital, Klinisk Farmakologisk Enhed, Klinisk Biokemisk Afdeling, København NV.
Ugeskr Laeger. 2007 May 7;169(19):1793-7.
Epidemiology describing poisoned patients treated at Copenhagen University Hospital, Bispebjerg has not been published since 1993. We wanted to describe the pattern of intoxications.
A retrospective study of poisoned patients admitted to the emergency ward during 2001. A computer search of patients discharged with codes T36.0-T65.9 was supplemented by a hand search of the daily admittance lists.
355 patients with confirmed poisonings were found. 97% were poisoned by medications, alcohol (ethanol) or drugs of abuse. Only 3% were poisoned by other agents such as CO. 55% of poisonings were intentional, where paracetamol and benzodiazepines were the preferred agents. Sedative-hypnotics, alcohol, opioids, and drugs of abuse dominated the unintentional overdoses. Patients poisoned by paracetamol were younger and female, with an overrepresentation of young women of foreign origin. Activated charcoal was the preferred method of gastric decontamination. In 52% of the cases various discrepancies between discharge codes and actual poisonings were found. There were 5 deaths, 2 of which were from mixed overdoses with benzodiazepines involving the administration of flumazenil. The 355 cases represented 6% of all patients admitted to the department.
Paracetamol, sedative-hypnotics and alcohol were the most common poisoning agents. Mortality was 1%. A general problem of discharge coding was found, which might implicate unreliability in statistics in this field.
自1993年以来,尚未发表过关于在哥本哈根大学医院比斯佩比约格分院接受治疗的中毒患者的流行病学情况。我们希望描述中毒模式。
对2001年期间入住急诊病房的中毒患者进行回顾性研究。通过计算机检索出院编码为T36.0-T65.9的患者,并辅以人工查阅每日入院清单。
共发现355例确诊中毒患者。97%的患者因药物、酒精(乙醇)或滥用药物中毒。只有3%的患者因一氧化碳等其他物质中毒。55%的中毒是故意的,对乙酰氨基酚和苯二氮䓬类药物是首选药物。镇静催眠药、酒精、阿片类药物和滥用药物在无意过量中毒中占主导地位。对乙酰氨基酚中毒的患者更年轻且以女性居多,外国年轻女性占比过高。活性炭是洗胃去污的首选方法。在52%的病例中,发现出院编码与实际中毒情况存在各种差异。有5例死亡,其中2例是因苯二氮䓬类药物混合过量并使用氟马西尼导致的。这355例病例占该科室所有入院患者的6%。
对乙酰氨基酚、镇静催眠药和酒精是最常见的中毒药物。死亡率为1%。发现了出院编码的一个普遍问题,这可能意味着该领域统计数据的不可靠性。