Anane S, Anane Touzri R, Malouche N, El Aich F, Beltaief O, Zhioua R, Kaouech E, Belhaj S, Kallel K, Jeddi A, Meddeb Ouertani A, Chaker E
Laboratoire de parasitologie-mycologie, hôpital la Rabta, 15, Djebel Lakhdar Street, 1007 Tunis, Tunisie.
Pathol Biol (Paris). 2007 Sep;55(7):323-7. doi: 10.1016/j.patbio.2007.03.005. Epub 2007 May 29.
The chronic blepharitis is a current ophthalmic disease posing a therapeutic problem. The etiologic diagnosis is essential for adapting the treatment.
The aim of this study is to describe the role of Demodex sp, Malassezia sp and Candida sp in the pathogenesis of chronic blepharitis.
It's a prospective study realized during a period of 14 months. It interested 69 patients with chronic blepharitis and 96 controls. The prevalence of Demodex sp, Malassezia sp and Candida sp on the eyelash of chronic blepharitis patients and controls was investigated.
Demodex folliculorum was found in 58% of patients with chronic blepharitis and in 15,6% of controls. The difference between the two groups was statistically significant (P<0,00001). The sex and the age intervene neither in the frequency, nor in the abundance of D. folliculorum in the two groups. Malassezia sp was identified in 10,4% of the control group and 31,88% of the group with chronic blepharitis. The difference is significant (P<0,00001). There is no correlation between frequency and abundance of Malassezia, sex and age in the two groups.
In our study, D. folliculorum and Malassezia sp seem to be accused in the genesis of the chronic blepharitis. Their systematic search is necessary in order to adapt the treatment.
慢性睑缘炎是一种当前存在治疗难题的眼科疾病。病因诊断对于调整治疗至关重要。
本研究旨在描述蠕形螨属、马拉色菌属和念珠菌属在慢性睑缘炎发病机制中的作用。
这是一项为期14个月的前瞻性研究。研究对象为69例慢性睑缘炎患者和96例对照者。调查了慢性睑缘炎患者和对照者睫毛上蠕形螨属、马拉色菌属和念珠菌属的患病率。
58%的慢性睑缘炎患者和15.6%的对照者检出毛囊蠕形螨。两组之间的差异具有统计学意义（P<0.00001）。性别和年龄在两组中对毛囊蠕形螨的频率和数量均无影响。马拉色菌属在10.4%的对照组和31.88%的慢性睑缘炎组中被鉴定出来。差异具有统计学意义（P<0.00001）。两组中马拉色菌的频率和数量、性别和年龄之间均无相关性。
在我们的研究中，毛囊蠕形螨和马拉色菌属似乎与慢性睑缘炎的发生有关。为了调整治疗，对它们进行系统检查是必要的。
