相对脑血容量是脑结核瘤中血管生成的一种测量指标。
Relative cerebral blood volume is a measure of angiogenesis in brain tuberculoma.
作者信息
Gupta Rakesh K, Haris Mohammad, Husain Nuzhat, Husain Mazhar, Prasad Kashi N, Pauliah Mohan, Srivastava Chhitiz, Tripathi Mukesh, Rastogi Manu, Behari Sanjay, Singh Anup, Rathore Divya, Rathore Ram Kishore S
机构信息
Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
出版信息
J Comput Assist Tomogr. 2007 May-Jun;31(3):335-41. doi: 10.1097/01.rct.0000243443.10739.16.
OBJECTIVE
The aim of this study was to correlate the perfusion indices with magnetic resonance imaging-derived cellular and necrotic fraction of the tuberculoma and angiogenesis metrics on histopathology.
METHODS
We performed dynamic contrast-enhanced magnetic resonance imaging in 13 excised brain tuberculoma patients. Microvascular density and vascular endothelial growth factor (VEGF)-expressing cells were quantified from the excised tuberculoma. The cellular and necrotic fractions of the tuberculomas were quantified on a postcontrast T1-weighted imaging.
RESULTS
Relative cerebral blood volume of cellular portion significantly correlated with cellular fraction volume (r = 0.882, P < 0.001), microvascular density (r = 0.900, P < 0.001), and VEGF (r = 0.886, P < 0.001) of the 13 excised tuberculomas. Microvascular density also correlated significantly with VEGF (r = 0.919, P < 0.001).
CONCLUSIONS
Relative cerebral blood volume is a measure of angiogenesis in the cellular fraction of the brain tuberculoma. This information may be of value in predicting the therapeutic response in future.
目的
本研究旨在将灌注指数与结核瘤的磁共振成像衍生的细胞和坏死分数以及组织病理学上的血管生成指标相关联。
方法
我们对13例切除的脑结核瘤患者进行了动态对比增强磁共振成像。从切除的结核瘤中对微血管密度和表达血管内皮生长因子（VEGF）的细胞进行定量。在对比剂增强后的T1加权成像上对结核瘤的细胞和坏死分数进行定量。
结果
13例切除的结核瘤的细胞部分的相对脑血容量与细胞分数体积（r = 0.882，P < 0.001）、微血管密度（r = 0.900，P < 0.001）和VEGF（r = 0.886，P < 0.001）显著相关。微血管密度也与VEGF显著相关（r = 0.919，P < 0.001）。
结论
相对脑血容量是脑结核瘤细胞部分血管生成的一种度量。该信息可能对预测未来的治疗反应有价值。
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