Laquieze Sabine, Czernielewski Janusz, Baltas Eszter
PERITESCO, Paris, France.
J Dermatolog Treat. 2007;18(3):158-62. doi: 10.1080/09546630601121078.
Rosacea is a common and chronic disorder characterized by flushing, erythema, papules, pustules, and telangiectasia on the central part of the face. Because the facial skin of individuals with rosacea is particularly sensitive, irritants can trigger a worsening of the signs and symptoms of the disease. This enhanced sensitivity is thought to be linked to a deficient stratum corneum barrier function.
In the present study, 20 individuals receiving twice-daily applications of metronidazole 0.75% gel for at least 15 days applied a gentle non-irritating moisturizing cream (Cetaphil Moisturizing Cream) twice daily for 15 days on one half of the face; the other side remained treated with metronidazole only and served as the control.
Clinical assessments, confirmed by biophysical measurements (electrical capacitance, transepidermal water loss (TEWL), and lactic acid stinging test), provided evidence that the moisturizer contributed to the restoration of the skin barrier: skin dryness, roughness and desquamation were much improved and skin sensitivity was significantly reduced. Skin properties and skin discomfort were also greatly enhanced and the patients were very satisfied with the product.
It can thus be concluded that in the management of rosacea, basic skin care regimens, including daily use of a therapeutic moisturizer, offer optimal benefits.
酒渣鼻是一种常见的慢性疾病,其特征为面部中央出现潮红、红斑、丘疹、脓疱和毛细血管扩张。由于酒渣鼻患者的面部皮肤特别敏感,刺激物可引发该病体征和症状的恶化。这种增强的敏感性被认为与角质层屏障功能缺陷有关。
在本研究中,20名每天两次使用0.75%甲硝唑凝胶至少15天的受试者,在面部的一半区域每天两次涂抹温和无刺激的保湿霜(丝塔芙保湿霜),持续15天;另一侧仅继续使用甲硝唑作为对照。
临床评估经生物物理测量(电容、经表皮水分流失(TEWL)和乳酸刺痛试验)证实,有证据表明该保湿剂有助于皮肤屏障的恢复:皮肤干燥、粗糙和脱屑情况得到显著改善,皮肤敏感性明显降低。皮肤特性和皮肤不适感也大大增强,患者对该产品非常满意。
因此可以得出结论,在酒渣鼻的治疗中,包括每日使用治疗性保湿霜在内的基本皮肤护理方案具有最佳益处。