Peng Yiran, Mao Mengping, Huang Ziyang, Zhao Huimin, Li Ying, Jian Dan
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.
J Cosmet Dermatol. 2025 Mar;24(3):e70025. doi: 10.1111/jocd.70025.
Mild erythema is a common affliction of rosacea. Many methods including drugs and phototherapy (e.g., Intense Pulse Light, IPL) have been tried to alleviate symptoms. Topical applications for enhancing moisturization have also been thought to be of some benefit. In this study, the improvement of erythema and skin physiology parameters were assessed after a topical serum (5% gluconolactone-based serum) usage or a single IPL treatment, and the differences in improvement between the two groups were compared. The treatment willingness of the subjects was also performed.
In this study, 200 subjects with mild erythema were enrolled; 100 of them were treated with topical serum (TS) for 30 consecutive days and the other 100 for a single IPL treatment. Facial images, local skin images, and physiological measurements were collected before and after treatment, to assess erythema (CEA), overall facial condition (VAS), and other skin physiology parameters (e.g., pore, skin tone, and sebum). Based on the questionnaire, the treatment willingness and satisfaction of the subjects were collected.
Improvement on erythema, overall facial condition, and skin physiology parameters were observed in two groups. Both subjective assessments and measurements showed greater efficacy in erythema reduction, overall facial condition improvement, and sebum reduction in the IPL group (p < 0.05). Pores and skin tone improvement were comparable in TS and IPL groups. Similarly, subjects with certain erythema improvement in both groups were satisfied with their choice of treatment, in which possible side effects, cost, and duration of the treatment somewhat influence their treatment decisions.
Topical serum that focuses on redness reduction and moisturization and IPL can improve erythema and skin physiological indicators. IPL is more capable of improving the overall facial appearance. By fully understanding the patient's facial condition and treatment influence, medical practitioners determine the appropriate treatment.
ClinicalTrials.gov identifier: ChiCTR2400087665.
轻度红斑是酒渣鼻的常见症状。人们尝试了许多方法，包括药物和光疗（如强脉冲光，IPL）来缓解症状。增强保湿的局部应用也被认为有一定益处。在本研究中，评估了使用局部血清（5%葡萄糖酸内酯基血清）或单次IPL治疗后红斑和皮肤生理参数的改善情况，并比较了两组改善情况的差异。还对受试者的治疗意愿进行了评估。
本研究纳入了200名患有轻度红斑的受试者；其中100名连续30天接受局部血清（TS）治疗，另外100名接受单次IPL治疗。在治疗前后收集面部图像、局部皮肤图像和生理测量数据，以评估红斑（CEA）、面部整体状况（VAS）和其他皮肤生理参数（如毛孔、肤色和皮脂）。根据问卷，收集受试者的治疗意愿和满意度。
两组均观察到红斑、面部整体状况和皮肤生理参数有所改善。主观评估和测量均显示，IPL组在减少红斑、改善面部整体状况和减少皮脂方面疗效更佳（p < 0.05）。TS组和IPL组在毛孔和肤色改善方面相当。同样，两组中红斑有一定改善的受试者对其治疗选择感到满意，其中可能的副作用、成本和治疗持续时间在一定程度上影响了他们的治疗决策。
专注于减轻发红和保湿的局部血清以及IPL均可改善红斑和皮肤生理指标。IPL更能改善面部整体外观。通过充分了解患者的面部状况和治疗影响，医生来确定合适的治疗方法。
ClinicalTrials.gov标识符：ChiCTR2400087665。
