Matsui Takuya, Ito Chihiro, Itoigawa Masataka, Okada Tadashi, Furukawa Hiroshi
Faculty of Pharmacy, Meijo University, Tempaku-ku, Nagoya, Aichi, Japan.
Planta Med. 2007 Jun;73(7):662-5. doi: 10.1055/s-2007-981528. Epub 2007 May 31.
Two phenylpropanoids, 1-allyl-3,5-dimethoxy-4-(3-methyl-but-2-enyloxy)benzene ( 4) and 4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol ( 6), and two phytoquinoids, 4 R-(-)-illicinone-A ( 7) and 2 S,4 R-(-)-illicinone-B ( 8), isolated from plants of the ILLICIUM species significantly inhibited histamine release from rat basophilic leukemia (RBL-2H3) cells stimulated with A23187. Furthermore, these compounds caused a decline in TNF-alpha levels in culture supernatants of RBL-2H3 cells following treatment with A23187. The results indicate that these compounds might be useful as anti-inflammatory agents against mast cell-mediated inflammatory diseases.
从八角属植物中分离出的两种苯丙素类化合物，1-烯丙基-3,5-二甲氧基-4-(3-甲基丁-2-烯氧基)苯(4)和4-烯丙基-2,6-二甲氧基-3-(3-甲基-2-丁烯基)苯酚(6)，以及两种植物醌类化合物，4R-(-)-八角酮-A(7)和2S,4R-(-)-八角酮-B(8)，能显著抑制A23187刺激的大鼠嗜碱性白血病(RBL-2H3)细胞释放组胺。此外，这些化合物在用A23187处理后的RBL-2H3细胞培养上清液中导致肿瘤坏死因子-α水平下降。结果表明，这些化合物可能作为抗肥大细胞介导的炎症性疾病的抗炎剂。
