da Fonseca Marcio A, Murdoch-Kinch Carol Anne
Section of Pediatric Dentistry, The Ohio State University College of Dentistry/Columbus Children's Hospital, Columbus, Ohio, USA.
Spec Care Dentist. 2007 Mar-Apr;27(2):59-63. doi: 10.1111/j.1754-4505.2007.tb00329.x.
Graft versus host disease (GVHD) occurs after a hematopoietic stem cell transplantation (HSCT) when the donor's immune system rejects the recipient's body, leading to significant morbidity and mortality. Increased numbers of chronic GVHD (c-GVHD) patients are likely to be seen by dental professionals because of the advances made in transplantation. The oral cavity may be the primary or the only site of c-GVHD and may have persistent lesions after resolution has occurred in other areas. Approximately 80% of patients with extensive c-GVHD present some type of oral involvement, including xerostomia, oral pain and lesions. Dental and oral care can be challenging for these patients. This paper discusses the manifestations and treatment of oral c-GVHD and presents the case history of a 15-month-old girl who developed severe oral GVHD with an unusual periodontal presentation and early loss of primary teeth.
移植物抗宿主病（GVHD）发生在造血干细胞移植（HSCT）后，此时供体的免疫系统排斥受体的身体，导致显著的发病率和死亡率。由于移植技术的进步，越来越多的慢性移植物抗宿主病（c-GVHD）患者可能会被牙科专业人员诊治。口腔可能是c-GVHD的主要或唯一发病部位，在其他部位病情缓解后口腔病变可能仍会持续存在。约80%的广泛性c-GVHD患者存在某种类型的口腔受累，包括口干、口腔疼痛和病变。对这些患者而言，牙齿和口腔护理颇具挑战性。本文讨论了口腔c-GVHD的表现和治疗，并介绍了一名15个月大女孩的病例，该女孩出现了严重的口腔GVHD，伴有不寻常的牙周表现和乳牙过早脱落。
