Taweevisit Mana
Department of Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 2007 Jan;38(1):136-40.
Abstract. The author investigated the p53 status in correlation with cellular proliferation in the undifferentiated subgroup, which is infrequently found in caucasians. The author evaluated formalin-fixed, paraffin embedded tissue blocks from sixty cases with undifferentiated carcinoma of the nasopharynx by p53 and Ki67 immunostaining. All samples were retrieved from the surgical pathology file at King Chulalongkorn Memorial Hospital from 2001-2005. The patients had a mean age of 47 years. Stage IV was the most common stage, found in 21 cases (35%). Forty-four tumors (73%) overexpressed p53 protein, which was significantly associated with high rate of tumor cell proliferation (r = 0.477, p < 0.001). The higher the amount of p53 stained, the higher the rate of tumor cell proliferation. However, there was no statistically significant association between p53 protein overexpression and clinical status, including tumor volume, nodal status, and metastatic condition. This observation may explain why some tumors are resistant to radiation and are poorly controlled when they recur in distant organs.
摘要。作者研究了p53状态与未分化亚组细胞增殖的相关性，该亚组在白种人中很少见。作者通过p53和Ki67免疫染色评估了60例鼻咽未分化癌的福尔马林固定、石蜡包埋组织块。所有样本均取自朱拉隆功国王纪念医院2001年至2005年的外科病理档案。患者的平均年龄为47岁。IV期是最常见的阶段，有21例（35%）。44个肿瘤（73%）p53蛋白过表达，这与肿瘤细胞高增殖率显著相关（r = 0.477，p < 0.001）。p53染色量越高，肿瘤细胞增殖率越高。然而，p53蛋白过表达与临床状态之间无统计学显著关联，包括肿瘤体积、淋巴结状态和转移情况。这一观察结果可能解释了为什么一些肿瘤对放疗耐药，且复发至远处器官时难以控制。
