Wang Hai-gang, Zhai Guang-xi, Lü Qing-zhi, Ling Pei-xue
School of Pharmacy, Shandong University, Jinan 250012, China.
Zhong Yao Cai. 2007 Jan;30(1):89-92.
To prepare chitosan coated puerarin liposomes and investigate their physicochemical properties.
Puerarin liposomes were prepared by reverse phase evaporation technique and then coated with chitosan. Using encapsulation efficiency as index of examination and designing an orthogonal experiment, the optimal formulation of liposomes was determined. The physicochemical properties of uncoatd and chitosan coated puerarin liposomes were investigated, respectively.
Uncoated and chitosan coated puerarin liposomes were spherelike and smooth. The mean particles size of uncoated and coated liposomes were 217. 3nm and 632. 6nm, respectively. The Zeta potential were -14.44 mV and +35.61 mV, respectively. The encapsulating efficency was 50. 6% and 51.1%, respectively.
Puerarin liposomes can be prepared by reverse phase evaporation technique successfully. The chitosan coated purarin liposomes ware spherelike and smooth.
制备壳聚糖包衣的葛根素脂质体并研究其理化性质。
采用逆相蒸发法制备葛根素脂质体，然后用壳聚糖进行包衣。以包封率为考察指标，设计正交试验，确定脂质体的最佳处方。分别考察未包衣和壳聚糖包衣的葛根素脂质体的理化性质。
未包衣和壳聚糖包衣的葛根素脂质体呈球形且表面光滑。未包衣和包衣脂质体的平均粒径分别为217.3nm和632.6nm。Zeta电位分别为-14.44mV和+35.61mV。包封率分别为50.6%和51.1%。
逆相蒸发法可成功制备葛根素脂质体。壳聚糖包衣的葛根素脂质体呈球形且表面光滑。
