van den Bree Marianne B M, Rice Frances, Fowler Tom A, Shelton Katherine H, Lifford Kate J, Scourfield Jane, Harold Gordon T, Thapar Anita
Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom.
Twin Res Hum Genet. 2007 Feb;10(1):13-23. doi: 10.1375/twin.10.1.13.
The study of twins and their families provides a highly useful tool for disentangling the genetic and environmental origins of traits. The Cardiff Study of All Wales and North West of England Twins (CaStANET) has followed children and adolescents over time into early adulthood, assessing a wide range of aspects of behavior and psychopathology using self-, parent and teacher reports. Four main waves of data collection have taken place to date, which have provided a wealth of information on the contributions of genetic and environmental risk factors to the psychological health of young people. This article first describes the CaStANET register and subsequently presents some of the findings that have emerged from this resource, with a focus on depression and anxiety, chronic fatigue, attention-deficit/hyperactivity disorder, conduct problems and prosocial behavior. We describe in somewhat more detail the 4th wave of data collection, which has recently been completed and has provided us with extensive information on substance use and problem use as well as associated risk factors in the twins and their families, including longitudinal data on conduct problems and the relations between family members. Because of the wealth of data already collected and the opportunity for genetically informative analyses over time, CaStANET provides a valuable resource for understanding the complexities of the psychological development of young people.
对双胞胎及其家庭的研究为厘清性状的遗传和环境起源提供了一个非常有用的工具。威尔士全境及英格兰西北部双胞胎卡迪夫研究（CaStANET）长期跟踪儿童和青少年直至成年早期，通过自我报告、父母报告和教师报告评估行为和精神病理学的广泛方面。迄今为止已进行了四轮主要的数据收集，这些数据提供了关于遗传和环境风险因素对年轻人心理健康影响的丰富信息。本文首先介绍CaStANET登记册，随后展示从该资源中得出的一些研究结果，重点关注抑郁和焦虑、慢性疲劳、注意力缺陷多动障碍、行为问题和亲社会行为。我们将更详细地描述最近完成的第四轮数据收集，它为我们提供了关于双胞胎及其家庭中物质使用和问题使用以及相关风险因素的广泛信息，包括行为问题的纵向数据和家庭成员之间的关系。由于已经收集了大量数据，并且随着时间推移有机会进行基因信息分析，CaStANET为理解年轻人心理发展的复杂性提供了宝贵资源。
