Huynh Tu Khai, Lee Lawrence R, Ellis David
The Royal Brisbane Hospital, Herston, Queensland, Australia.
Clin Exp Ophthalmol. 2007 May-Jun;35(4):366-8. doi: 10.1111/j.1442-9071.2007.01486.x.
This is the first documented case of Phaeoacremonium parasiticum endophthalmitis to the authors' knowledge. P. parasiticum has been described in the literature causing various skin, subcutaneous and joint infections and one case of infective endocarditis, but has never been documented as an ocular infectious agent. The most likely source of inoculation in this case was a penetrating injury caused by a stick 5 years prior to the presentation. An enucleation was avoided through treatment with intravitreal antibiotics and amphotericin and oral voriconazole, and the patient's vision stabilized at 6/18. Microbiological studies were delayed but confirmed the mould's sensitivity to amphotericin B and voriconazole.
据作者所知，这是首例有文献记载的寄生拟青霉性眼内炎病例。文献中已描述寄生拟青霉可引起各种皮肤、皮下和关节感染以及一例感染性心内膜炎，但从未被记载为眼部感染病原体。该病例最可能的接种源是5年前就诊前由一根树枝造成的穿透伤。通过玻璃体内注射抗生素、两性霉素和口服伏立康唑进行治疗，避免了眼球摘除，患者视力稳定在6/18。微生物学研究虽有所延迟，但证实了该霉菌对两性霉素B和伏立康唑敏感。
