Fujisawa Tomoyuki, Suda Takafumi, Matsuura Shun, Enomoto Noriyuki, Takeshita Kaori, Ohnishi Kazunori, Chida Kingo
Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Respirology. 2007 May;12(3):452-4. doi: 10.1111/j.1440-1843.2007.01057.x.
Peripheral T-cell lymphoma is a subtype of non-Hodgkin's lymphoma. A case of peripheral T-cell lymphoma showing diffuse pulmonary involvement together with a marked increase in the level of serum KL-6 is presented. CXR and CT revealed reticular and ground-glass opacities, which mimicked interstitial pneumonia. Immunopathological findings and an analysis of T-cell receptor gene rearrangements of the lung biopsy specimen led to a definite diagnosis of peripheral T-cell lymphoma. In addition, the extensive proliferation of type II pneumocytes, which stained strongly positive for anti-KL-6 antibody suggested that the pneumocytes were the source of serum KL-6.
外周T细胞淋巴瘤是非霍奇金淋巴瘤的一种亚型。本文报告1例外周T细胞淋巴瘤，其表现为弥漫性肺受累，同时血清KL-6水平显著升高。胸部X线片和CT显示网状及磨玻璃样阴影，类似间质性肺炎。肺活检标本的免疫病理检查结果及T细胞受体基因重排分析确诊为外周T细胞淋巴瘤。此外，II型肺泡上皮细胞大量增殖，抗KL-6抗体染色呈强阳性，提示这些肺泡上皮细胞是血清KL-6的来源。
