Wang Dayong, Wang Yang
Department of Genetics and Developmental Biology, Southeast University, Nanjing, China.
Environ Pollut. 2008 Feb;151(3):585-92. doi: 10.1016/j.envpol.2007.04.003. Epub 2007 May 30.
Whether the multiple biological toxicities from nickel exposure could be transferred to progeny has not been clarified. In this report, we explored the Caenorhabditis elegans to analyze the multiple toxicities of nickel and their possibly transferable properties. The nickel toxicity caused multiple biological defects in a concentration-dependent manner. Moreover, most of these toxicities could be transferred and could be only partially rescued in progeny. Some specific phenotypes in progeny were also found to exhibit no obvious rescue phenotypes or to show even more severe defects than their parents. The defects caused by nickel exposure could be classified into four groups according to their transferring properties. That is, the defects caused by nickel exposure could be largely, or partially, or unable to be rescued, or became even more severe in progeny animals. Therefore, most of the nickel exposure-caused defects can be transferred from parents to their progeny to different degrees in C. elegans.
镍暴露产生的多种生物毒性是否会传递给后代尚不清楚。在本报告中，我们利用秀丽隐杆线虫来分析镍的多种毒性及其可能的可传递特性。镍毒性以浓度依赖的方式导致多种生物缺陷。此外，这些毒性大多可以传递，并且在后代中只能部分得到挽救。还发现后代中的一些特定表型没有明显的挽救表型，甚至比其亲本表现出更严重的缺陷。根据其传递特性，镍暴露引起的缺陷可分为四类。也就是说，镍暴露引起的缺陷在后代动物中可能大部分、部分或无法得到挽救，或者变得更加严重。因此，在秀丽隐杆线虫中，大多数镍暴露引起的缺陷能够不同程度地从亲代传递给子代。
