Song Joon Young, Kee Sae Yoon, Hwang In Sook, Seo Yu Bin, Jeong Hye Won, Kim Woo Joo, Cheong Hee Jin
Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of Korea.
J Antimicrob Chemother. 2007 Aug;60(2):317-22. doi: 10.1093/jac/dkm136. Epub 2007 May 31.
To determine the in vitro activities and interactions of imipenem, colistin and tigecycline with old antibacterial agents against carbapenem-resistant Acinetobacter baumannii.
Forty-three carbapenem-resistant A. baumannii isolates from the intensive care unit of a university hospital were collected and their MICs of imipenem, colistin and tigecycline were determined. With eight randomly selected carbapenem-resistant isolates, an in vitro time-kill study was performed for the evaluation of antibacterial activity of colistin, tigecycline, imipenem/sulbactam and colistin/rifampicin.
The time-kill study of colistin demonstrated bactericidal activity against A. baumannii at concentrations of 4xMIC and 8xMIC, whereas tigecycline showed bacteriostatic activity at all concentrations. The combination regimens of imipenem/sulbactam and colistin/rifampicin were synergistic and bactericidal at 1xMIC.
Imipenem/sulbactam combination, colistin and tigecycline showed good in vitro activities against carbapenem-resistant A. baumannii isolates. Even though colistin is bactericidal against carbapenem-resistant A. baumannii, the colistin/rifampicin combination is more warranted in order to be certain.
确定亚胺培南、黏菌素和替加环素与旧有抗菌药物对耐碳青霉烯鲍曼不动杆菌的体外活性及相互作用。
收集某大学医院重症监护病房的43株耐碳青霉烯鲍曼不动杆菌分离株，测定其对亚胺培南、黏菌素和替加环素的最低抑菌浓度（MIC）。选取8株随机挑选的耐碳青霉烯分离株进行体外时间杀菌研究，以评估黏菌素、替加环素、亚胺培南/舒巴坦和黏菌素/利福平的抗菌活性。
黏菌素的时间杀菌研究表明，在4倍MIC和8倍MIC浓度下对鲍曼不动杆菌具有杀菌活性，而替加环素在所有浓度下均显示抑菌活性。亚胺培南/舒巴坦和黏菌素/利福平联合用药方案在1倍MIC时具有协同杀菌作用。
亚胺培南/舒巴坦联合用药、黏菌素和替加环素对耐碳青霉烯鲍曼不动杆菌分离株显示出良好的体外活性。尽管黏菌素对耐碳青霉烯鲍曼不动杆菌具有杀菌作用，但为确保疗效，黏菌素/利福平联合用药更有必要。
