Reeves Matthew F, Smith Kenneth J, Creinin Mitchell D
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine and the Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213-3180, USA
Obstet Gynecol. 2007 Jun;109(6):1286-94. doi: 10.1097/01.AOG.0000265336.14160.cc.
To model rates of pregnancy and repeat abortion among women choosing intrauterine contraception after an abortion when the intrauterine device (IUD) is inserted immediately after the procedure or at a follow-up visit.
We created an evidence-based decision model of women desiring to avoid pregnancy for the 12 months after an abortion. Base case assumptions were pregnancy rates of 0.5% with an IUD and 20% without an IUD, 1-year IUD continuation rate of 80%, an additional 5% risk of IUD expulsion with immediate insertion, and a 35% risk of not returning for a follow-up visit for IUD insertion. Sensitivity analyses and Monte Carlo simulation were performed.
Immediate IUD insertion after abortion prevented 52 pregnancies over the following year for every 1,000 women modeled by using base case assumptions. Sensitivity analyses show the model to be most dependent on the rate of expulsion in the immediate-insertion group and the proportion not returning in the delayed-insertion group. Monte Carlo analysis showed that immediate insertion resulted in fewer pregnancies than delayed insertion in 91% of scenarios, with an absolute mean difference of 28 pregnancies per 1,000 women in the initial year after abortion. If 20% of U.S. women undergoing abortion opted for immediate insertion, an estimated 20,000 repeat abortions would be prevented in the first year.
Women who have an IUD inserted immediately after an abortion are expected to have fewer pregnancies and repeat abortions than women scheduled for insertion of an IUD at a follow-up visit.
建立一个模型,用以评估在人工流产后选择宫内避孕的女性中,于手术结束后立即插入宫内节育器(IUD)或在随访时插入IUD的妊娠率和重复流产率。
我们为希望在人工流产后12个月内避免怀孕的女性创建了一个基于证据的决策模型。基本假设为:使用IUD时妊娠率为0.5%,不使用IUD时妊娠率为20%;IUD 1年持续使用率为80%;立即插入IUD时,IUD排出的额外风险为5%;未返回进行IUD插入随访的风险为35%。进行了敏感性分析和蒙特卡洛模拟。
根据基本假设,在每1000名接受建模的女性中,人工流产后立即插入IUD在接下来的一年中可预防52次妊娠。敏感性分析表明,该模型最依赖于立即插入组的IUD排出率和延迟插入组未返回的比例。蒙特卡洛分析表明,在91%的情况下,立即插入比延迟插入导致的妊娠更少,在人工流产后的第一年,每1000名女性的绝对平均差异为28次妊娠。如果20%接受人工流产的美国女性选择立即插入IUD,预计第一年可预防20000次重复流产。
与计划在随访时插入IUD的女性相比,人工流产后立即插入IUD的女性预计妊娠和重复流产的次数会更少。