Mousa Noha A, Bedaiwy Mohamed A, Casper Robert F
Institute of Medical Science, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Obstet Gynecol. 2007 Jun;109(6):1421-3. doi: 10.1097/01.AOG.0000265807.19397.6d.
Endometriosis-associated chronic pelvic pain unresponsive to surgical menopause is a difficult clinical problem.
A middle-aged woman presented with endometriosis and severe pelvic pain after hysterectomy and bilateral salpingo-oopherectomy. She was first treated with exemestane without improvement of symptoms. However, another aromatase inhibitor, letrozole, relieved her pain, and concomitant treatment with estrogen relieved hot flushes without pain reactivation.
Letrozole was superior to exemestane in relieving the endometriosis-associated pain in this postmenopausal woman. This suggests that patients may respond variably to different aromatase inhibitors.
与子宫内膜异位症相关的慢性盆腔疼痛对手术绝经无反应是一个棘手的临床问题。
一名中年女性在子宫切除和双侧输卵管卵巢切除术后出现子宫内膜异位症和严重盆腔疼痛。她首先接受依西美坦治疗，但症状未改善。然而，另一种芳香化酶抑制剂来曲唑缓解了她的疼痛，同时使用雌激素治疗潮热，且疼痛未复发。
在缓解这名绝经后女性的子宫内膜异位症相关疼痛方面，来曲唑优于依西美坦。这表明患者对不同的芳香化酶抑制剂可能有不同反应。
