Miller Jessica E, Ahn Soo Hyun, Monsanto Stephany P, Khalaj Kasra, Koti Madhuri, Tayade Chandrakant
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Oncotarget. 2017 Jan 24;8(4):7138-7147. doi: 10.18632/oncotarget.12577.
Endometriosis is a complex, inflammatory disease that affects 6-10% of reproductive-aged women. Almost half of the women with endometriosis experience infertility. Despite the excessive prevalence, the pathogenesis of endometriosis and its associated infertility is unknown and a cure is not available. While many theories have been suggested to link endometriosis and infertility, a consensus among investigators has not emerged. In this extensive review of the literature as well as research from our laboratory, we provide potential insights into the role of immune dysfunction in endometriosis associated infertility. We discuss the implication of the peritoneal inflammatory microenvironment on various factors that contribute to infertility such as hormonal imbalance, oxidative stress and how these could further lead to poor oocyte, sperm and embryo quality, impaired receptivity of the endometrium and implantation failure.
子宫内膜异位症是一种复杂的炎症性疾病，影响6%-10%的育龄妇女。几乎一半的子宫内膜异位症患者会出现不孕。尽管患病率很高，但子宫内膜异位症及其相关不孕的发病机制尚不清楚，也没有治愈方法。虽然已经提出了许多理论来联系子宫内膜异位症和不孕，但研究人员尚未达成共识。在对文献以及我们实验室研究的广泛综述中，我们对免疫功能障碍在子宫内膜异位症相关不孕中的作用提供了潜在的见解。我们讨论了腹膜炎症微环境对导致不孕的各种因素的影响，如激素失衡、氧化应激，以及这些因素如何进一步导致卵母细胞、精子和胚胎质量差、子宫内膜容受性受损和植入失败。
