Räikkönen Katri, Pesonen Anu-Katriina, Kajantie Eero, Heinonen Kati, Forsén Tom, Phillips David I W, Osmond Clive, Barker David J P, Eriksson Johan G
Department of Psychology, University of Helsinki, PO Box 9, 00014 University of Helsinki, Finland.
Br J Psychiatry. 2007 Jun;190:469-74. doi: 10.1192/bjp.bp.106.022145.
A non-optimal foetal environment, reflected in smaller birth size and shorter duration of gestation, is a risk factor for compromised health later in life.
To examine whether smaller birth size and shorter gestation predict depressive symptoms.
A total of 1371 members of a cohort born between 1934 and 1944 at term (259-294 days'gestation) in Helsinki, Finland, completed the Beck Depression Inventory (BDI) and the Center for Epidemiological Studies Depression scale (CES-D) at an average age of 61.5 years (BDI) and 63.4 years (BDI and CES-D).
Gestational length predicted depressive symptoms linearly and independently of gender and birth weight: per day decrease in gestational length, depressive symptoms scores increased by 0.8-0.9% (95% CI 0.2-1.4, P<0.009). Weight, length and head circumference at birth showed no linear association with depression, adjusted for gender and gestational length. The results did not change when further controlled for socio-economic characteristics at birth and in adulthood, age and body mass index in adulthood.
Susceptibility to depressive symptoms may relate to shorter length of gestation.
胎儿生长环境不佳，表现为出生时体重较轻和孕期较短，是日后健康受损的一个风险因素。
研究出生时体重较轻和孕期较短是否可预测抑郁症状。
芬兰赫尔辛基1934年至1944年足月（孕期259 - 294天）出生的队列中的1371名成员，平均年龄61.5岁（使用贝克抑郁量表时）和63.4岁（使用贝克抑郁量表和流行病学研究中心抑郁量表时），完成了贝克抑郁量表（BDI）和流行病学研究中心抑郁量表（CES - D）。
孕期长短可独立于性别和出生体重，呈线性方式预测抑郁症状：孕期每天缩短，抑郁症状评分增加0.8 - 0.9%（95%置信区间0.2 - 1.4，P < 0.009）。在对性别和孕期长短进行校正后，出生时的体重、身长和头围与抑郁无线性关联。在进一步控制出生时和成年后的社会经济特征、年龄及成年后的体重指数后，结果不变。
抑郁症状易感性可能与孕期较短有关。
