Räikkönen Katri, Pesonen Anu-Katriina, Heinonen Kati, Kajantie Eero, Hovi Petteri, Järvenpää Anna-Liisa, Eriksson Johan G, Andersson Sture
Department of Psychology, University of Helsinki, PO Box 9, FI-00014 Helsinki, Finland.
Arch Gen Psychiatry. 2008 Mar;65(3):290-6. doi: 10.1001/archgenpsychiatry.2007.40.
Little is known about the mental health outcomes of very low-birth-weight (VLBW) (< 1500 g) infants in young adulthood.
To test whether young adults aged 18 to 27 years with VLBW differ from term control subjects in depressive symptoms, current use of antidepressant medication, and the rate of depression diagnosed by a physician.
Retrospective longitudinal study.
Academic research.
A total of 162 VLBW young adults (response rate, 65.1%) and 172 term control subjects (response rate, 54.8%) born between February 22, 1978, and November 8, 1985, in Helsinki, Finland.
Antidepressant use, history of physician-diagnosed depression, Beck Depression Inventory score, and Center for Epidemiologic Studies Depression Scale score.
The VLBW participants reported 20.1% (95% confidence interval [CI], -40.8% to -5.1%) lower CES-D scores than the controls (P =.02). However, this finding was confined to 110 VLBW participants who were born appropriate for gestational age (birth weight > or = -2 SDs according to Finnish birth weight charts), whose Center for Epidemiologic Studies Depression Scale scores were 29.1% (95% CI, -53.7% to -8.4%) lower than those of the controls (P =.004). Furthermore, VLBW participants born appropriate for gestational age were 4.8 (95% CI, 1.3-10.0) times less likely to report a depression diagnosis than controls (P =.02). In contrast, 52 VLBW participants born small for gestational age (birth weight < -2 SDs according to Finnish birth weight charts) reported 36.2% (95% CI, 1.1%-83.5%) higher Beck Depression Inventory scores (P =.04), were 4.0 (95% CI, 1.1-14.3) times more likely to use antidepressants (P =.03), and were 2.5 (95% CI, 1.0-6.3) times more likely to report a depression diagnosis (P =.04) compared with controls.
This is the first study (to our knowledge) to show that intrauterine growth pattern may modify associations between VLBW and depression. Intrauterine growth retardation rather than VLBW per se may pose a risk of depression in young adulthood.
关于极低出生体重（VLBW，<1500克）婴儿成年早期的心理健康状况，人们知之甚少。
检验18至27岁的极低出生体重青年与足月对照受试者在抑郁症状、当前抗抑郁药物使用情况以及医生诊断的抑郁症发病率方面是否存在差异。
回顾性纵向研究。
学术研究机构。
1978年2月22日至1985年11月8日在芬兰赫尔辛基出生的162名极低出生体重青年（应答率65.1%）和172名足月对照受试者（应答率54.8%）。
抗抑郁药物使用情况、医生诊断抑郁症的病史、贝克抑郁量表评分以及流行病学研究中心抑郁量表评分。
极低出生体重参与者报告的流行病学研究中心抑郁量表评分比对照组低20.1%（95%置信区间[CI]，-40.8%至-5.1%）（P = 0.02）。然而，这一发现仅限于110名适于胎龄出生的极低出生体重参与者（根据芬兰出生体重图表，出生体重>或=-2个标准差），他们的流行病学研究中心抑郁量表评分比对照组低29.1%（95%CI，-53.7%至-8.4%）（P = 0.004）。此外，适于胎龄出生的极低出生体重参与者报告抑郁症诊断的可能性比对照组低4.8倍（95%CI，1.3 - 10.0）（P = 0.02）。相比之下，52名小于胎龄出生的极低出生体重参与者（根据芬兰出生体重图表，出生体重<-2个标准差）报告的贝克抑郁量表评分高36.2%（95%CI，1.1% - 83.5%）（P = 0.04），使用抗抑郁药物的可能性比对照组高4.0倍（95%CI，1.1 - 14.3）（P = 0.03），报告抑郁症诊断的可能性比对照组高2.5倍（95%CI，1.0 - 6.3）（P = 0.04）。
据我们所知，这是第一项表明子宫内生长模式可能改变极低出生体重与抑郁症之间关联的研究。子宫内生长迟缓而非极低出生体重本身可能在成年早期带来患抑郁症的风险。
