Mazzawi Jeffrey Miles, Henson Timothy, Donly Kevin J
Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Am J Dent. 2007 Apr;20(2):134-6.
To investigate the efficacy of a bioerodible fluoridated resin on inhibition of enamel demineralization.
Eighteen extracted permanent molars were sectioned mesiodistally to obtain 36 caries-free enamel surfaces. Each sample was prepared by painting an acid-protective varnish, excluding a 2 x 8 mm window on either the buccal or lingual surface. The windows of exposed enamel were randomly divided into three separate groups (n = 12). Group 1 received an application of a 5% (by weight) sodium fluoride varnish. Group 2 had an experimental 5% sodium fluoride bioerodible resin applied to the window. Group 3 was left untreated and acted as a control. The samples were then exposed to an artificial caries challenge for 17 days, until a visible white spot lesion had been created on the control group. The samples were brushed for 1 minute daily. Following the acid challenge, the teeth were sectioned longitudinally to obtain 100 microm sections. Sections were then photographed under polarized light. Quantitatively the areas of the lesions were measured by utilizing a computerized imaging system. Finally, a comparison was made between mean lesion sizes of the sample groups in order to determine their respective efficacy of enamel demineralization inhibition.
The mean areas (microm)2 of the artificial lesions (+/- SD) were: bioerodible fluoridated resin 3,785 +/- 1,794; fluoride varnish 7,362 +/- 2,853, and control 11,398 +/- 4,238. ANOVA was performed and identified a significant variance (P < 0.001). Tukey's multiple comparison test demonstrated that bioerodible fluoridated resin had significantly less enamel demineralization than the fluoride varnish and control groups (P < 0.05). The fluoride varnish group demonstrated significantly less enamel demineralization than the control group (P < 0.05).
研究一种可生物降解的含氟树脂对抑制牙釉质脱矿的效果。
将18颗拔除的恒牙沿近远中方向切片，获得36个无龋的牙釉质表面。每个样本通过涂抹酸保护漆制备，在颊面或舌面留出一个2×8毫米的窗口。将暴露牙釉质的窗口随机分为三个独立组（n = 12）。第1组涂抹5%（重量）的氟化钠漆。第2组在窗口涂抹实验性的5%氟化钠可生物降解树脂。第3组不做处理作为对照。然后将样本暴露于人工龋损刺激17天，直到对照组出现可见的白斑病变。样本每天刷牙1分钟。酸刺激后，将牙齿纵向切片获得100微米厚的切片。然后在偏光下对切片进行拍照。利用计算机成像系统定量测量病变面积。最后，比较样本组的平均病变大小，以确定它们各自抑制牙釉质脱矿的效果。
人工病变的平均面积（微米）2（±标准差）为：可生物降解含氟树脂3785±1794；氟化钠漆7362±2853，对照组11398±4238。进行方差分析并确定存在显著差异（P < 0.001）。Tukey多重比较检验表明，可生物降解含氟树脂的牙釉质脱矿明显少于氟化钠漆组和对照组（P < 0.05）。氟化钠漆组的牙釉质脱矿明显少于对照组（P < 0.05）。
