Lin Royana, Hildebrand Travis, Donly Kevin J
Department of Pediatric Dentistry, Dental School, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Am J Dent. 2009 Aug;22(4):203-5.
To examine the remineralization effects of a bioerodible fluoridated resin.
36 extracted permanent molars were suspended into an artificial caries solution to create an artificial caries-like lesion. Teeth were sectioned longitudinally to obtain 100 microm sections containing the artificial caries-like lesion, then photographed with polarized light microscopy in an imbibition media of water, representing a minimum of 5% pore volume. An acid-resistant varnish was applied to the surfaces of the sections, leaving only the natural external tooth surface and caries-like lesion exposed. The external tooth surface of 12 samples had 5% sodium fluoride varnish applied, 12 samples had 5% sodium fluoride bioerodible resin applied, and the remaining samples acted as controls. The sections were returned to the tooth, placed in an artificial saliva solution and brushed daily for 30 days. The sections were removed and photographed under polarized light as before. Using a computerized imaging system, the area of the body of the lesion was measured, comparing the same section before and after the 30-day experimental period to evaluate the remineralization process.
The mean percent area remineralization (+/-SD) was: bioerodible fluoridated resin 44.1 +/- 12.1; fluoride varnish 19.1 +/- 9.2; control 2.4 +/- 3.4. ANOVA indicated a significant variance among groups (P < 0.001). Tukey's multiple comparison test demonstrated the fluoridated resin to enhance remineralization significantly greater (P < 0.001) than the fluoride varnish and control and the fluoride varnish to enhance remineralization significantly greater (P < 0.002) than the control.
研究一种生物可蚀性含氟树脂的再矿化效果。
将36颗拔除的恒牙悬浮于人工龋溶液中以形成人工龋样病变。将牙齿纵向切片以获得包含人工龋样病变的100微米切片，然后在水的浸润介质中用偏光显微镜拍照，水代表至少5%的孔隙体积。在切片表面涂上抗酸清漆，仅使天然牙齿外表面和龋样病变暴露。12个样本的牙齿外表面涂有5%的氟化钠清漆，12个样本涂有5%的生物可蚀性含氟树脂，其余样本作为对照。将切片放回牙齿，置于人工唾液溶液中，每天刷牙30天。如前所述，取出切片并在偏光下拍照。使用计算机成像系统测量病变体的面积，比较30天实验期前后的同一切片以评估再矿化过程。
平均再矿化面积百分比（±标准差）为：生物可蚀性含氟树脂44.1±12.1；氟化钠清漆19.1±9.2；对照2.4±3.4。方差分析表明各组间存在显著差异（P< 0.001）。Tukey多重比较检验表明，含氟树脂的再矿化增强作用显著大于（P< 0.001）氟化钠清漆和对照，氟化钠清漆的再矿化增强作用显著大于（P< 0.002）对照。
