卵巢成熟性囊性畸胎瘤中发生的鳞状细胞癌：其肿瘤发生的免疫组织化学分析
Squamous cell carcinoma arising in mature cystic teratoma of the ovary: an immunohistochemical analysis of its tumorigenesis.
作者信息
Iwasa A, Oda Y, Kaneki E, Ohishi Y, Kurihara S, Yamada T, Hirakawa T, Wake N, Tsuneyoshi M
机构信息
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Histopathology. 2007 Jul;51(1):98-104. doi: 10.1111/j.1365-2559.2007.02727.x. Epub 2007 Jun 1.
AIMS
Squamous cell carcinoma (SCC) is the most common form of malignant transformation in mature cystic teratoma (MCT) of the ovary. Some investigators have suggested the possibility of origin from columnar epithelium. The aim of this study was to analyse such tumours immunohistochemically to elucidate their histogenesis.
METHODS AND RESULTS
The expression of cytokeratin (CK) 10 and CK18 was examined in 21 samples of SCC arising in MCT. The expression of CK10 and CK18 was also assessed in SCCs arising in different organs (skin, vulva, lung and uterine cervix) for the purpose of comparison. SCC in MCT expressed CK10 in 7/21 cases [33.3%, 95% confidence interval (CI) 0.12-0.53] and CK18 in 14/21 cases (66.7%, 95% CI 0.46-0.87). SCC in MCT expressed CK10 less frequently, but CK18 more frequently, as is the case in SCCs of the uterine cervix (CK10, 20%; CK18, 70%) and the lung (CK10, 5%; CK18, 90%), both of which are derived from columnar epithelium by squamous metaplasia.
CONCLUSIONS
SCC in MCT may be derived from metaplastic squamous epithelium.
目的
鳞状细胞癌（SCC）是卵巢成熟囊性畸胎瘤（MCT）中最常见的恶性转化形式。一些研究者提出其可能起源于柱状上皮。本研究旨在通过免疫组织化学分析此类肿瘤以阐明其组织发生。
方法与结果
检测了21例MCT中发生的SCC样本中细胞角蛋白（CK）10和CK18的表达。为作比较，还评估了不同器官（皮肤、外阴、肺和子宫颈）发生的SCC中CK10和CK18的表达。MCT中的SCC有7/21例（33.3%，95%置信区间[CI] 0.12 - 0.53）表达CK10，14/21例（66.7%，95% CI 0.46 - 0.87）表达CK18。MCT中的SCC表达CK10的频率低于子宫颈SCC（CK10，20%；CK18，70%）和肺SCC（CK10，5%；CK18，90%），而后两者均通过鳞状化生起源于柱状上皮。
结论
MCT中的SCC可能起源于化生的鳞状上皮。
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