Chemli J, Ketata S, Dalhoumi A, Ajmi H, Hassayoun S, Fodha I, Boujaafar N, Harbi A
Service de pédiatrie, CHU Sahloul, 4054 Sousse, Tunisie.
Arch Pediatr. 2007 Aug;14(8):1003-6. doi: 10.1016/j.arcped.2007.04.010. Epub 2007 May 31.
Mycoplasma pneumoniae infection is associated with various manifestations involving the central nervous system but it has never been reported as a potential aetiology of opsoclonus-myoclonus syndrome (OMS) in children.
We report on a case in a 4-year-old girl who presented neurological manifestations compatible with an OMS, after a respiratory tract disease. Aetiological investigations revealed M. pneumoniae infection as specific IgM were present in the serum (Elisa). Evolution after corticosteroid, intravenous immunoglobulins and macrolide therapy was favourable as clinical symptoms disappeared. After a 12-month follow-up, the patient has no neurological sequela.
M. pneumoniae infection should be added to the list of causes to be screened in OMS. Its pathophysiology remains unknown but may involve a dysimmune postinfectious mechanism.
肺炎支原体感染与涉及中枢神经系统的各种表现有关，但从未被报道为儿童眼阵挛-肌阵挛综合征（OMS）的潜在病因。
我们报告一例4岁女孩病例，该女孩在呼吸道疾病后出现了与OMS相符的神经学表现。病因学调查显示血清中存在肺炎支原体感染特异性IgM（酶联免疫吸附测定）。在接受皮质类固醇、静脉注射免疫球蛋白和大环内酯类药物治疗后病情好转，临床症状消失。经过12个月的随访，该患者没有神经后遗症。
肺炎支原体感染应被列入OMS需筛查的病因清单中。其病理生理学尚不清楚，但可能涉及感染后免疫失调机制。
