Witt Claudia M, Bluth Michael, Albrecht Henning, Weisshuhn Thorolf E R, Baumgartner Stephan, Willich Stefan N
Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, D-10098 Berlin, Germany.
Complement Ther Med. 2007 Jun;15(2):128-38. doi: 10.1016/j.ctim.2007.01.011. Epub 2007 Mar 28.
Systematic assessment of the in vitro research on high potency effects.
Publications of experiments were collected through databases, experts, previous reviews, citation tracking.
stepwise agitated dilutions <10(-23); cells or molecules from human or animal. Experiments were assessed with the modified SAPEH score.
From 75 publications, 67 experiments (1/3 of them replications) were evaluated. Nearly 3/4 of them found a high potency effect, and 2/3 of those 18 that scored 6 points or more and controlled contamination. Nearly 3/4 of all replications were positive. Design and experimental models of the reviewed experiments were inhomogenous, most were performed on basophiles.
Even experiments with a high methodological standard could demonstrate an effect of high potencies. No positive result was stable enough to be reproduced by all investigators. A general adoption of succussed controls, randomization and blinding would strengthen the evidence of future experiments.
对高效能效应的体外研究进行系统评估。
通过数据库、专家、既往综述、引文追踪收集实验出版物。
逐步振荡稀释<10(-23)；来自人类或动物的细胞或分子。实验采用改良的SAPEH评分进行评估。
从75篇出版物中，评估了67项实验（其中1/3为重复实验）。近3/4的实验发现了高效能效应，在18项得6分或更高且控制了污染的实验中，有2/3发现了高效能效应。所有重复实验中近3/4为阳性。所审查实验的设计和实验模型不一致，大多数实验是在嗜碱性粒细胞上进行的。
即使是方法学标准较高的实验也能证明高效能效应。没有一个阳性结果足够稳定，能被所有研究者重复。普遍采用振荡对照、随机化和盲法将加强未来实验的证据。
