Edmison John, McCullough Arthur J
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA.
Clin Liver Dis. 2007 Feb;11(1):75-104, ix. doi: 10.1016/j.cld.2007.02.011.
Non-alcoholic fatty liver disease (NAFLD) has moved rapidly to the forefront of clinical disease, with a prevalence of 30% in the adult United States population and a definite but yet uncertain rate of progression to cirrhosis and end-stage liver disease. This disease has an impact on all areas of clinical medicine, with increasing prevalence and adversity. It is essential to understand the pathophysiologic mechanisms involved in NAFLD, so that therapeutic strategies can be developed. Although fatty liver may be caused by other factors, this review concentrates on fatty liver associated with insulin resistance, sometimes referred to as the primary form.
非酒精性脂肪性肝病（NAFLD）已迅速成为临床疾病的前沿问题，在美国成年人群中的患病率为30%，其发展为肝硬化和终末期肝病的发生率明确但尚不确定。这种疾病对临床医学的各个领域都有影响，且患病率和危害性不断增加。了解NAFLD所涉及的病理生理机制至关重要，以便能够制定治疗策略。虽然脂肪肝可能由其他因素引起，但本综述重点关注与胰岛素抵抗相关的脂肪肝，有时也称为原发性形式。
