Kaverina N V, Arefolov V A, Grigor'eva E K, Panasiuk L V
Farmakol Toksikol. 1976 Jun-Aug;39(4):420-5.
Nonachlazine (2 micrometer) blocked significantly the uptake 1 of endogenic noradrenaline in the myocardial tissues and in adrenergic neurons of vas deferens. The uptake II, as well as the intensity and dynamics of the noradrenaline release were not affected by nonachlazine. These processes resulted in an increase of free noradrenaline concentrations in the synaptic space. The latter seems to be a result of the mediator's passage into the nerve fibers (through axonal membranes) and into the granule, this being due to the nonachlazine-induced block. It is suggested that the metabolic and functional nonachlazine effects are related to the beta-adrenergic receptors stimulation, mediated through the agency of noradrenaline.
去甲氯氮平（2微米）显著阻断了心肌组织和输精管肾上腺素能神经元中内源性去甲肾上腺素的摄取1。摄取II以及去甲肾上腺素释放的强度和动力学不受去甲氯氮平影响。这些过程导致突触间隙中游离去甲肾上腺素浓度增加。后者似乎是由于介质通过轴突膜进入神经纤维并进入颗粒，这是由去甲氯氮平诱导的阻断所致。有人提出，去甲氯氮平的代谢和功能作用与通过去甲肾上腺素介导的β-肾上腺素能受体刺激有关。
