Arefolov V A, Panasiuk L V, Firsov V K
Farmakol Toksikol. 1975 May-Jun;38(3):285-9.
Cytochemical electron microscopy was employed to study the content of neurotransmitters in the synaptic vesicles of adrenergic nerve fibers of Vas deferens of the rat following depletion of the meadiator's reserves by tyramine and subsequent accumulation of exogenous norepinephrine. Subject to investigation was also the effect of antidepressants (phthoracizine and imipramine) on the accumulation of exogenous norepinephrine in the synaptic vesicles. Phthoracizine and imipramine (1 and 10 gamma/ml) are shown to block the acculation of norepinephrine in the vesicles, when the mediator is introduced in a concentration of 0,5 gamma/ml, and not to impede this process, if the mediator's concentration is increased to 30 gamma/ml.
运用细胞化学电子显微镜技术，研究了用酪胺耗尽介质储备并随后积累外源性去甲肾上腺素后大鼠输精管肾上腺素能神经纤维突触小泡中神经递质的含量。还研究了抗抑郁药（福索嗪和丙咪嗪）对外源性去甲肾上腺素在突触小泡中积累的影响。当以0.5微克/毫升的浓度引入介质时，福索嗪和丙咪嗪（1和10微克/毫升）可阻断去甲肾上腺素在小泡中的积累；而当介质浓度增加到30微克/毫升时，则不妨碍这一过程。
