Monroe Matthew E, Tolić Nikola, Jaitly Navdeep, Shaw Jason L, Adkins Joshua N, Smith Richard D
Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Bioinformatics. 2007 Aug 1;23(15):2021-3. doi: 10.1093/bioinformatics/btm281. Epub 2007 Jun 1.
The accurate mass and time (AMT) tag approach is used for analysis of large scale experiments by combining information generated over multiple datasets and instrument types. The VIPER software package is one of the key components of the data processing pipeline and implements automated algorithms to discover LC-MS features, align and match these LC-MS features to a database of peptides previously identified in LC-MS/MS analyses, and identify and quantify pairs of isotopically labeled peptides.
VIPER may be downloaded free of charge at http://ncrr.pnl.gov/software/
精确质量与时间（AMT）标签方法通过整合多个数据集和仪器类型生成的信息，用于大规模实验的分析。VIPER软件包是数据处理流程的关键组件之一，它实现了自动化算法，以发现液相色谱-质谱（LC-MS）特征，将这些LC-MS特征与先前在LC-MS/MS分析中鉴定出的肽段数据库进行比对和匹配，并识别和定量同位素标记肽段对。
