Lockhart Staci M, Rathbun R Chris, Stephens Johnny R, Baker Damon L, Drevets Douglas A, Greenfield Ronald A, Salvaggio Michelle R, Vincent Simi
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
AIDS. 2007 Jun 19;21(10):1370-3. doi: 10.1097/QAD.0b013e32811ebf9e.
Adverse drug reactions causing the early discontinuation of therapy are common in patients with HIV infection. Hypersensitivity consisting mainly of a maculopapular rash on the face, extremities and trunk has been observed at a rate higher than expected in patients treated with tenofovir at our clinics. We therefore examined nine patients with suspected tenofovir hypersensitivity reactions in two indigent care HIV clinics. Type I and type IV hypersensitivity may be involved as immunological mechanisms.
导致治疗提前中断的药物不良反应在HIV感染患者中很常见。在我们诊所接受替诺福韦治疗的患者中，主要表现为面部、四肢和躯干斑丘疹的超敏反应发生率高于预期。因此，我们在两家贫困护理HIV诊所检查了9例疑似替诺福韦超敏反应的患者。I型和IV型超敏反应可能作为免疫机制参与其中。
