Department of Dermatology, Command Hospital, Pune, Maharashtra, India.
Indian J Pharmacol. 2012 Sep-Oct;44(5):651-3. doi: 10.4103/0253-7613.100407.
A 50-year-old man, a known case of human immunodeficiency virus infection for the past 1 year, was on antiretroviral therapy in the form of stavudine, lamivudine, and nevirapine. Three days after replacing stavudine with tenofovir, he developed redness on the face and neck and within 48 h the rash became generalized. Dermatological examination revealed involvement of photoexposed areas of the face in the form of erythema and ill-defined hyperpigmented plaques, with mild periorbital edema. There was specific involvement of V and nape of the neck. Extensive erythema and scaling were also present on buttocks, thighs, and upper third of legs. A diagnosis of photoallergic dermatitis to tenofovir was considered and confirmed by histopathology and photopatch test. He responded well to the stoppage of the drug and oral corticosteroids. This is the first report of a photoallergic reaction to tenofovir in the literature.
一位 50 岁男性，过去 1 年已知患有人类免疫缺陷病毒感染，正在接受拉米夫定、司他夫定和奈韦拉平的抗逆转录病毒治疗。在替诺福韦取代司他夫定后 3 天，他的面部和颈部出现发红，48 小时内皮疹变得广泛。皮肤科检查显示面部光暴露区域受累，表现为红斑和界限不清的色素沉着斑块，伴有轻度眶周水肿。V 区和颈后也有特定的受累。臀部、大腿和腿部上三分之一也存在广泛的红斑和鳞屑。考虑到他对替诺福韦发生了光过敏性皮炎，并通过组织病理学和光斑贴试验得到了证实。他停止使用该药物和口服皮质类固醇后反应良好。这是文献中首例替诺福韦光过敏反应的报告。
