疾病状态标志物PD-L1的表达在无病毒血症患者中不会因高效抗逆转录病毒治疗（HAART）而降低。
Expression of PD-L1, a marker of disease status, is not reduced by HAART in aviraemic patients.
作者信息
Rosignoli Guglielmo, Cranage Alison, Burton Catherine, Nelson Mark, Steel Alan, Gazzard Brian, Gotch Frances, Imami Nesrina
机构信息
Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, UK.
出版信息
AIDS. 2007 Jun 19;21(10):1379-81. doi: 10.1097/QAD.0b013e3281de7296.
Anergy and defective immune responses are characteristic of chronic HIV-1 infection. The programmed death 1 (PD-1)/PD-1 ligand (PD-L1) pathway appears to be involved in downregulating T-cell functionality. We found raised levels of PD-L1 in aviraemic chronically infected HIV-1-positive patients, which may contribute to incomplete immune reconstitution after treatment with HAART.
无反应性和免疫应答缺陷是慢性HIV-1感染的特征。程序性死亡1（PD-1）/PD-1配体（PD-L1）通路似乎参与下调T细胞功能。我们发现，在无病毒血症的慢性感染HIV-1阳性患者中，PD-L1水平升高，这可能导致高效抗逆转录病毒治疗（HAART）后免疫重建不完全。
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