Thorburn Andrew
Department of Pharmacology and University of Colorado Comprehensive Cancer Center, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80010, USA.
J Thorac Oncol. 2007 Jun;2(6):461-5. doi: 10.1097/JTO.0b013e31805fea64.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo1L is a death ligand, a cytokine that activates apoptosis through cell surface death receptors. TRAIL is thought to be important in host tumor surveillance and metastasis suppression, and various therapeutic agonists that activate TRAIL receptors to induce tumor cell apoptosis are in clinical development. This review discusses recent findings about TRAIL pathway signaling and relates the signaling mechanisms to issues that need to be considered as we try to manipulate TRAIL signaling to treat cancer.
肿瘤坏死因子相关凋亡诱导配体（TRAIL）/Apo1L是一种死亡配体，是一种通过细胞表面死亡受体激活凋亡的细胞因子。TRAIL被认为在宿主肿瘤监测和转移抑制中起重要作用，并且各种激活TRAIL受体以诱导肿瘤细胞凋亡的治疗性激动剂正在临床开发中。本综述讨论了关于TRAIL途径信号传导的最新发现，并将信号传导机制与我们试图操纵TRAIL信号传导来治疗癌症时需要考虑的问题联系起来。
