Tavakoli M B, Evans J A
Department of Medical Physics, University of Leeds, Leeds General Infirmary, UK.
Phys Med Biol. 1991 Nov;36(11):1529-37. doi: 10.1088/0031-9155/36/11/012.
Measurements of the attenuation and velocity of ultrasound from 0.3 to 0.8 MHz have been performed on a number of bovine cancellous bone samples. The influence of bone mineral content has been isolated by measuring the acoustic properties of the samples at various stages of demineralization resulting from controlled nitric acid attack. The correlation coefficient r, between the attenuation at different frequencies and bone density was found to be in the range 0.68-0.97. Broadband ultrasonic attenuation (BUA) was also calculated and produced r values between 0.84 and 0.99. The velocity measurements indicated a correlation greater than 0.97 in all cases. Thus velocity is the parameter most sensitive to changes in bone mineral density alone. Attenuation and BUA are less well correlated presumably because of a sensitivity to minor structural change.
已对多个牛松质骨样本进行了0.3至0.8兆赫兹超声衰减和速度的测量。通过测量因受控硝酸侵蚀导致脱矿质不同阶段样本的声学特性，分离出了骨矿物质含量的影响。发现不同频率下的衰减与骨密度之间的相关系数r在0.68至0.97范围内。还计算了宽带超声衰减（BUA），其r值在0.84至0.99之间。速度测量表明在所有情况下相关性均大于0.97。因此，速度是仅对骨矿物质密度变化最敏感的参数。衰减和BUA的相关性较差，可能是因为对微小结构变化敏感。
