妊娠期糖尿病及产后早期的血清抵抗素
Serum resistin in gestational diabetes mellitus and early postpartum.
作者信息
Chen Danqing, Fang Qin, Chai Yun, Wang Hanzhi, Huang Hefeng, Dong Minyue
机构信息
Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Road, Hangzhou 310006, China.
出版信息
Clin Endocrinol (Oxf). 2007 Aug;67(2):208-11. doi: 10.1111/j.1365-2265.2007.02862.x. Epub 2007 Jun 4.
OBJECTIVES
To observe the alterations in serum resistin in gestational diabetes (GDM) and the early postpartum period, and compare this to nondiabetic pregnancies in order to evaluate the role of serum resistin in gestational diabetes mellitus.
DESIGN
A cross-sectional study.
PATIENTS
Twenty women with normal pregnancy and 20 with gestational diabetes.
MEASUREMENTS
Serum resistin concentration was assayed by ELISA.
RESULTS
Serum resistin concentration was significantly higher in women with GDM than in controls before delivery. Serum levels of resistin significantly decreased after delivery in both the GDM group and controls (P < 0.001 for both). There was a trend of higher serum resistin in women with GDM than in controls. Differences existed on days 1 (P < 0.001) and 3 (P = 0.013), but not by day 5 (P = 0.052) after delivery.
CONCLUSIONS
Elevated serum resistin level was observed in women with gestational diabetes, suggesting that it is important in the pathology of the disease.
目的
观察妊娠期糖尿病（GDM）患者及产后早期血清抵抗素的变化，并与非糖尿病妊娠患者进行比较，以评估血清抵抗素在妊娠期糖尿病中的作用。
设计
横断面研究。
研究对象
20例正常妊娠女性和20例妊娠期糖尿病女性。
测量方法
采用酶联免疫吸附测定法（ELISA）检测血清抵抗素浓度。
结果
分娩前，GDM患者血清抵抗素浓度显著高于对照组。GDM组和对照组产后血清抵抗素水平均显著下降（两组P均<0.001）。GDM患者血清抵抗素水平有高于对照组的趋势。产后第1天（P<0.001）和第3天（P = 0.013）存在差异，但产后第5天无差异（P = 0.052）。
结论
妊娠期糖尿病女性血清抵抗素水平升高，提示其在该疾病病理过程中具有重要作用。
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