Akdeniz N, Kuyumcuoğlu U, Kale A, Arikan S, Kale E, Erdemoğlu M
Department of Gynecology and Obstetrics, Dicle University, School of Medicine, Diyarbakir, Turkey.
Clin Exp Obstet Gynecol. 2011;38(3):236-8.
Resistin is a potent regulator of glucose homeostasis which is thought to oppose the action of insulin in peripheral tissues. The aim of this study was to determine changes in resistin levels in gestational diabetes mellitus (GDM).
Twenty women with GDM (mean age 32.28 +/- 5.01 years old, and gestational age 32.2 +/- 4.8 weeks) matched with 22 non diabetic pregnant women (NGDM) (mean age 30.30 +/- 4.5 years old, and gestational age 34.8 +/- 3.5 weeks) were included in the study. Body mass index (BMI) was calculated. Serum resistin levels were measured and insulin resistance was calculated with HOMA-IR. The Mann Whitney U test was used for statistical analysis.
BMI was 33.8 +/- 6.2 kg/m2 in the GDM group and 28.4 +/- 6.2 kg/m2 in the NGDM group (p = 0.04). Serum resistin levels were 8.7 +/- 2.1 ng/ml in the GDM group and 8.1 +/- 2.5 ng/ml in the NGDM group. Mean resistin level was not different between the two groups. HOMA-IR in GDM was higher than in the NGDM group (13.2 +/- 12.2 vs 5.8 +/- 5.1, p = 0.02, respectively).
Although mean BMI in GDM was higher than in NGDM and insulin resistance in GDM was more marked than in NGDM, serum resistin levels in GDM were not found to be any different from NGDM.
抵抗素是葡萄糖稳态的强效调节因子，被认为在外周组织中拮抗胰岛素的作用。本研究旨在确定妊娠期糖尿病（GDM）患者抵抗素水平的变化。
本研究纳入了20例GDM患者（平均年龄32.28±5.01岁，孕周32.2±4.8周），并与22例非糖尿病孕妇（NGDM）（平均年龄30.30±4.5岁，孕周34.8±3.5周）进行匹配。计算体重指数（BMI）。测量血清抵抗素水平，并用HOMA-IR计算胰岛素抵抗。采用Mann-Whitney U检验进行统计分析。
GDM组的BMI为33.8±6.2kg/m²，NGDM组为28.4±6.2kg/m²（p = 0.04）。GDM组血清抵抗素水平为8.7±2.1ng/ml，NGDM组为8.1±2.5ng/ml。两组的平均抵抗素水平无差异。GDM组的HOMA-IR高于NGDM组（分别为13.2±12.2和5.8±5.1，p = 0.02）。
尽管GDM组的平均BMI高于NGDM组，且GDM组的胰岛素抵抗比NGDM组更明显，但未发现GDM组的血清抵抗素水平与NGDM组有任何差异。
