Izgüt-Uysal V Nimet, Bülbül Mehmet, Tan Ruken, Derin Narin, Ustünel Ismail, Ağar Aysel, Yargiçoğlu Piraye
Department of Physiology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
J Physiol Sci. 2007 Jun;57(3):187-92. doi: 10.2170/physiolsci.RP004707. Epub 2007 Jun 5.
L-Carnitine is an essential cofactor in the mitochondrial transfer of fatty acids, and it is also a scavenger of free radicals in mammalian tissues. The aim of the study was to determine the effect of L-carnitine on chronic restraint stress-induced gastric mucosal injury.
Wistar rats were applied restraint stress (1 h/day) and L-carnitine (50 mg/kg) for 21 days. The lesion index, prostaglandin E(2) and mucus content, lipid peroxidation, superoxide dismutase, and catalase activity in gastric mucosa were evaluated.
Chronic restraint stress increased the lesion index, lipid peroxidation, and superoxide dismutase activity in gastric mucosa, and it decreased prostaglandin E(2) and mucus content. L-Carnitine treatment prevented the stress-induced increase in lesion index, lipid peroxidation and a stress-induced decline in prostaglandin E(2), and mucus content in gastric mucosa, but it increased catalase activity.
L-Carnitine prevents the occurrence of lesion by strengthening the gastric mucosal barrier and by reducing lipid peroxidation against the harmful effects of chronic restraint stress.
左旋肉碱是脂肪酸线粒体转运过程中的一种必需辅助因子，也是哺乳动物组织中自由基的清除剂。本研究旨在确定左旋肉碱对慢性束缚应激诱导的胃黏膜损伤的影响。
将Wistar大鼠进行束缚应激（每天1小时）并给予左旋肉碱（50毫克/千克），持续21天。评估胃黏膜的损伤指数、前列腺素E2和黏液含量、脂质过氧化、超氧化物歧化酶和过氧化氢酶活性。
慢性束缚应激增加了胃黏膜的损伤指数、脂质过氧化和超氧化物歧化酶活性，并降低了前列腺素E2和黏液含量。左旋肉碱治疗可防止应激诱导的损伤指数增加、脂质过氧化以及应激诱导的胃黏膜前列腺素E2和黏液含量下降，但增加了过氧化氢酶活性。
左旋肉碱通过加强胃黏膜屏障和减少脂质过氧化来预防损伤的发生，以对抗慢性束缚应激的有害影响。
